correlation between electrocardiographic and histopathological changes in isoprenaline-induced myocardial injury

نویسندگان

keshav anand form the' dept. of physiology, medical school, kerman university of medical sciences, kerman

saroj pande dept. of physiology, maulana azad medical college, new delhi, india

rk gupta dept. of pathology, medical school, kermanuniversity of medical sciences, kerman, islamic republic of iran.

چکیده

myocardial injury was induced in 25 dogs by infusing isoprenaline, 2-4 microgram per kg per minute for the duration of six hours. 10 dogs served as controls which received only physiological saline. animals receiving isoprenaline 2 microgram per kg per minute were labelled as experimental group a and other receiving microgram per kg per minute as experimental group b. histopathological observations in experimental groups a & b showed subendocardial haemorrhage in the papillary muscles and apex of left ventricle as early as two-three hours of infusion. focal lesions characterized by congestion, dilatation and extravasation of blood was observed near necrotic myocardium. group a animals showed only severe tachycardia while in group b myocardial infarction in 80% and only ischaemic changes in 20% of animals were observed. out of animals in group b, 37.5% developed myocardial infarction after two hours of infusion while remaining 62.5% developed changes after four hours. histopathological changes were very well correlated with ecg findings observed in the present study.

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عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۴، شماره ۴، صفحات ۲۸۷-۲۹۱

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